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KMID : 0360419660020020047
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Korean Journal of Pharmacology
1966 Volume.2 No. 2 p.47 ~ p.53
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The Bacteriostatic Action of Trichlorophenoxy Alkylene Ammonium Derivatives and their synthesis
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姜信完/Kang, Shin Wang
車忠錫/尹熙正/金和雄/金重暎/李大秀/Cha, Choong Suk/Yun, Hea Chung/Kim, Hwa Woong/Kim, Chung Yung/Lee, Dae Soo
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Abstract
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The bacteriostatic action of trichlorophenoxy alkylene ammonium derivatives, 2(2,4,5-trichlorophenoxy) ethylene N-triethyl ammonium bromide;(2,4,5-TETB), 2(2,4,6-trichlorophenoxy) ethylene N-triethyl ammonium bromide;(2,4,6-TETB), 2,4,5-triphenoxy ethylene pyridinium bromide;(2,4,5-TETB), and 2,4,6-trichlorophenoxy ethylene pyridinium bromide;(2,4,6-TETB) were observed by Jackson and Finland´s and Pak´s method on Staphylococcus aureus, E. coli, Salmonella typhi, Shigella flexneri, and Bacillus subtilis, comparing with those of phenol and trichlorophenol. The following results were obtained.
1) Phenol is bacteriostatic in a concentration of 10^(-3) for all above species.
2) Trichlorophenol is bacteriostatic in concentration of 10^(-4) to 5×10^(-5) for all above species(Table 7).
3) 2,4,5-TETB and 2,4,6-TETB are bacteriostatic in a concentration of 10^(-4) and 5×10^(-5) for Staphylococcus aureus, Salmonella typhi, and Shigella flexneri, but do not for E. coli and Bacillus subtilis(Table 8 and 9).
4) 2,4,5-TETB and 2,4,6-TETB are bacteriostatic in a concentration of 10^(-4) and 5×10^(-5) only for Staphylococcus aureus among four species(Table 10 and 11).
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